D-1223

Active Ingredients: Solubilised Dihydrocoumarin androgen receptor ligand 50mg per ml.
Application: 1ml daily with food in the morning in protein shake (250ml liquid).
Ingredients: Vegetable glycerin, Dihydrocoumarin, and Flavour.
Legal Status: Legal in Australia, food additive FEMA.
Unique Points:
• Food Approved
• Clinical evidence of activity
• Palatable
• Non-carcinogenic

Follistatin modulation, on the other hand, can influence myostatin expression and achieve realistic results without negative effects on long term health. ,, New research (2014) has identified a specific chemical in Theobroma species. (-)-Epicatechin is similar to other polyphenols however carries the unique ability to up regulate follistatin by 2.5 times and directly down regulate myostatin. ,, Moreover it has also been linked to a lower risk of heart disease. The issue in the past was its low solubility and thus low bioavailability. Androl is a unique solubilised formula allowing a high level of bioavailability.

Dihydrocoumarin is a naturally occurring (in this case nature identical) compound found in Sweet Clover (Melilotus officionalis). Research considered whether dihydrocoumarin could inhibit the human NADþ- dependent deacetylase SIRT1 and observed that DHC induced a concentration-dependent inhibition of SIRT1 (IC50 of 208 microM) in an in vitro enzymatic assay. That is loosely equivalent to 2400mg for an 80kg individual however a decrease in SIRT1 deacetylase activity was observed at micromolar doses with observed activity at as low as 1.6 microM (19mg). The microtubule SIRT2 deacetylase was also inhibited with a similar dose dependency. SIRT1 is a repressor of anabolic and androgenic activity and inhibits DHT mediated transcription thus by inhibiting SIRT1 and SIRT2, anabolic activates are promoted. SIRT1 inhibition also upregulates androgen receptor expression.